First published: April 20, 2021
Sustainability and green chemistry should be an important part of a peptide CDMOs corporate philosophy. A commitment and contribution to the environment is an integral part of AmbioPharm’s management structure, manufacturing policies, and corporate culture.
We are happy to be a part of the latest issue of Chemistry Today discussing pathways to sustainable production and discuss how AmbioPharm is moving towards green peptide chemistry.
Alternative Strategies Which Help Improve Sustainability and “Green” Peptide Manufacturing
Peptide production has evolved over the past 50 years into a mature industry of both contract development and pharmaceutical manufacturers. Key to this evolution were improvements to the solid-phase production methods which utilized Fmoc-tBu protection strategies. Inherent to peptide synthesis are principal issues which result in a large impact on the green and sustainability factors for this industry. Some of these include: regular use of both transient and semi-permanent protecting groups which diminish the atom efficiency, generation of large amounts of hazardous chemical waste, and energy inefficient processes such as lyophilization. This short review describes some of the initiatives in our industry such as “greener” solvents, recycling key solvents, and alternatives to lyophilization such as precipitation, crystallization or spray drying.
Link to the article is found here: https://www.teknoscienze.com/Contents/Riviste/Sfogliatore/CO2_2021/38/index.html