Why should you consider pegylated peptides?

We make several PEGylated peptides at large commercial scale. PEGylation adds a polyethylene glycol (PEG) polymer to target molecules through a covalent attachment. This may be via an amide linkage to a Lys or Cys residue via a maleimide linkage. PEGylation may help to enhance a peptide’s therapeutic properties by masking them from the host’s immune system, increasing their solubility (for hydrophobic drugs), and bioavailability. PEGS>20kD can slow renal clearance prolonging the circulating half-life time of the product in the host. Methoxy polyethylene glycol or m-PEG is the commonly used PEG polymer in peptides.

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