Why should we consider pegylated peptides?

We make several pegylated peptides at large commercial scale. PEGylation adds a polyethylene glycol polymer to target molecules through a covalent attachment. This may be via an amide linkage to a Lys residue or to a Cys residue via a maleimide linkage. PEGylation may help to enhance a peptide’s therapeutic properties by masking them from the host’s immune system, increasing their solubility (for hydrophobic drugs) and bioavailability. For Pegs >20kD, these slow renal clearance thereby prolonging the circulating half-life time of the product in the host.

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