Peptide production has evolved over the past 50 years into a mature industry of both contract development and pharmaceutical manufacturers. Key to this evolution were improvements to the solid-phase production methods which utilized Fmoc-tBu protection strategies. Inherent to peptide synthesis are principal issues which result in a large impact on the green and sustainability factors for this industry. Some of these include: regular use of both transient and semi-permanent protecting groups which diminish the atom efficiency, generation of large amounts of hazardous chemical waste, and energy inefficient processes such as lyophilization. This short review describes some of the initiatives in our industry such as “greener” solvents, recycling key solvents, and alternatives to lyophilization such as precipitation, crystallization or spray drying.