What is the maximum peptide length you can synthesize?

We can synthesize peptides of lengths up to ~80 residues. Peptide lengths of 10 to 70 residues can usually be made by direct solid phase peptide synthesis (SPPS) chemical synthesis. Depending upon the scale and future requirements, combined strategies of using solution fragment condensation or even hybrid methods involving solid-phase couplings of protected peptide fragments may be developed specifically for each product. We also can utilize native chemical ligation (NCL) to make longer peptides and potentially mini-proteins using fully deprotected peptide fragments with an N-terminal Cys residue and another fragment containing a C-terminal thioester. While we have successfully manufactured peptides >80 residues, peptides greater than 80 amino acids are often more viably manufactured via a recombinant synthesis. On the other hand, peptides with 2-10 amino acids are often manufactured by solution or liquid phase peptide synthesis (LPPS). See also our FAQ, How are Peptides Synthesized?

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